Studies on Chemotherapeutics. XXXIX

Clinical studies of induction agents. XXXIX: CT1341, a new steroid anaesthetic.

CT1341 is a new intravenous anaesthetic which appears to have overcome the disadvantages of the earlier steroid. The formulation is a mixture of two closely related steroids with Cremophor EL and the optimum dose for induction is 50-60 (J/kg though much larger doses can be given without serious side effects. As the dose is increased the incidence of muscle movements, respiratory depression and ...

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

The XXXIX Long Fox Memorial Lecture

Nanoformulations of Antimicrobial Chemotherapeutics

Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS and tuberculosis now represents about 85% of world mortality from infections [1,2]. The increase in the number of new inf...

Xxxix. the Precipitation of Egg-albumin